Oxygen administration is a crucial intervention in managing conditions associated with hypoxemia, such as COPD, pneumonia, and heart failure. It improves oxygen saturation, supports organ function, and enhances overall quality of life by alleviating symptoms like shortness of breath and fatigue. Nurses play a pivotal role in the safe and effective delivery of oxygen therapy, selecting appropriate methods, adjusting flow rates, and ensuring continuous patient monitoring. Nurses’ expertise is integral to adjusting oxygen therapy, mitigating risks, and improving patient well-being.