Nipah virus is a newly formed Zoonosis. Which causes significant mortality in human & causes impact on public health. According to WHO for animal health Niv is a notifiable disease important to international trades. Niv belongs to the family paramyxoviridae and is related to Hendra virus. Nipah virus is a single- Negative (-ve) standard RNA and its size range is from (40 – 1900nm) the presence of reticular cytoplasmic inclusion near to the endoplasmic reticulum distinguish the virus from paramyxoviruses. Fruit bats are identified as the natural reservoir host. Electron micro graph shows Nipah virus particles (purple) & Infected Vero cell shows (Brown). It is started from the state of Malaysia, Singapore & later in India, Kerala etc. Niv spreads from direct contact with infected animals like bats, pigs & their body fluids like Blood, urine, saliva & food products contamination by body fluids of animals. Niv common symptoms are fever, cold, headache respiratory problems etc. PCR & ELISA are the methods for diagnosis purpose. There is no specific medication or vaccine for the treatment of Nipah virus. Currently several clinical trials on vaccines are going on including mRNA – based vaccines. There is a lack of vaccine & therapeutic to cure this disease. Supportive medication used for the treatment of symptoms are Acetaminophen or ibuprofen, Dimenhydrinate or ondansetron, Dextromethorphan, ipratropium, or salbutamol.