Guillain-Barre syndrome (GBS) is a rare neurological disorder which manifests as a symmetrical motor paralysis that gradually ascends upward involving diaphragm and other respiratory muscles leaving the person unable to breathe on their own and landing upon catastrophe. A 23-year-old primigravida with 16 weeks of gestation presented to emergency room with bilateral progressive lower limb weakness, along with history of tetanus toxoid vaccination 4-5 days prior to this event. She developed respiratory failure in virtue of diaphragmatic involvement and was managed in critical care setting with airway management, ventilatory assistance along with multidisciplinary approach. She was successfully discharged from hospital after receiving immunoglobulin therapy and other supportive measures. Management of GBS in pregnancy has been discussed.