Injection is painful medical invasive procedure used commonly in hospitals for different diagnostic and treatment purposive. Children are more sensitive to pain response and incompliance during injection procedure. Nurses need to engaged the new medical technologies such ShotBlocker for reducing patients` pain, fear, trauma, and increase their compliance and wellbeing. This review is highlight on the previous studies that investigated the ShoBlocker device in their randomized control trail for alleviating children’s` pain during injection procedure.