Palliative care has emerged as a critical component in the holistic care of patients grappling with advanced or life-limiting illnesses like neuro-oncological conditions. It holds profound significance for both the medical community and patients and their families, as it addresses the pressing need to enhance patient well-being in the face of debilitating symptoms and offers potential for improved comfort during the challenging journey. Neuro-oncological disorders, including brain tumours, pose distinct challenges due to their intricate impact on cognitive and physical functioning. Despite the availability of treatments that may temporarily alleviate symptoms and extend life expectancy, brain tumours often culminate tragically, necessitating specialized palliative care Physical immobility, cognitive changes, motor function impairments, seizures, and delirium pose significant hurdles and are intricately influenced by the characteristics and progression of the underlying tumour. This comprehensive review aims to systematically examine the existing literature to illuminate the multifaceted dimensions of palliative care tailored to neuro-oncology patients.it also intends to provides an insightful overview of pivotal themes in palliative care such as symptomatic management, psychosocial support, advance care planning, and end-of-life care. It highlights the importance of embracing a multidisciplinary approach and early integration of palliative care into the patient’s journey. It also ventures into unexplored territories within the realm of neuro-oncology, exploring critical aspects like effectiveness of interventions, advance care planning, and often-overlooked needs of caregivers who play an indispensable role in the patient’s care trajectory. In conclusion, this review amplifies the vital significance of a comprehensive palliative care approach, emphasizing the need for sustained research endeavours and collaborative partnerships among healthcare providers, researchers, and stakeholders. Through these collective efforts, the aim is to substantially enhance the quality of care and support extended to patients and their families, offering a glimmer of hope, comfort, and dignity amid the challenges posed by these complex conditions.