Air pollution is one of the leading potent environmental problem in the modern world for all living creatures. It produces multiple health hazards like cardiovascular dieseses, respiratory diseases and skin diseases. However, air pollution is emerging as a leading risk factor for coronary artery disease. It promotes oxidative stress, systemic inflammation, autonomic dysfunction, metabolic dysregulation, hypercoagulability, and epigenetic changes. Individuals with genetic susceptibility face compounded risks, underscoring the need for personalized and public health interventions. Through a combination of behavioural, public awareness, medical and policy-driven strategies, the burden of air pollution-induced coronary artery disease can be significantly reduced.