Diabetic foot ulcers (DFUs) represent one of the most serious and debilitating complications of diabetes mellitus. Affecting a significant proportion of individuals with diabetes, DFUs are a leading cause of hospitalization and non-traumatic lowerlimb amputation worldwide, imposing substantial personal, social, and economic burdens. This paper provides a comprehensive overview of DFUs, exploring their complex pathogenesis driven primarily by peripheral neuropathy, peripheral artery disease (PAD), and infection. It details the clinical presentation, diagnostic approaches including assessment of wound characteristics and underlying systemic factors, and outlines the principles of multidisciplinary management. Key therapeutic strategies discussed include aggressive wound care (debridement and appropriate dressings), offloading, infection control, revascularization where indicated, and systemic metabolic optimization. Prevention, through patient education, regular foot examinations, and risk factor management, is emphasized as paramount in reducing the incidence of these challenging lesions. Addressing DFUs requires a coordinated effort from a diverse healthcare team to achieve limb salvage, prevent recurrence, and improve patient quality of life.