Pseudoexfoliation syndrome (PXS) is a systemic, age-related fibrillopathy characterized by the progressive accumulation of abnormal extracellular material throughout the body, most notably in the ocular tissues. This deposition can lead to a variety of ocular complications, including glaucoma, cataract, and zonular weakness, significantly impacting vision. This paper aims to provide a comprehensive overview of PXS, encompassing its epidemiology, pathogenesis, clinical manifestations, diagnosis, management, and current research directions.