Background: Rehabilitation aims to optimize function and reduce disability in children with physical impairments. Orthotic devices, such as splints and braces, are essential in preventing deformities and enhancing mobility. However, accessibility and adherence to orthotic use remain challenges, particularly in low-resource settings. Caregivers play a crucial role in ensuring compliance, yet their knowledge, attitudes, and willingness to invest in orthotic interventions are not well-documented in India. This study aimed to assess these factors among caregivers of children with physical disabilities. Methods: A cross-sectional observational study was conducted among 43 caregivers from the Mumbai Metropolitan Region. Participants were recruited using convenience sampling from physiotherapy clinics and special schools. Data were collected through a self-administered, validated questionnaire assessing knowledge, attitudes, and willingness to use orthotic devices. Descriptive statistics, chi-square tests, and logistic regression analyses were performed to determine associations between variables. Results: The majority of caregivers were female (72.1%) and aged 31–45 years (60.5%). Most children (81.4%) currently used an orthosis. Knowledge of orthosis was moderate, with only 18.6% being highly familiar. Attitudes varied, with 27.9% reporting positive perceptions and 39.5% remaining neutral. Willingness to invest in orthosis was reported by 46.5% of caregivers, though financial constraints were a major concern (69.8%). Attitude was the strongest predictor of willingness to invest (p = 0.001), while financial constraints and education level showed no significant influence. Conclusion: Caregivers’ attitudes significantly impact their willingness to invest in orthotic interventions, highlighting the need for targeted educational initiatives. Addressing misconceptions and financial barriers could enhance compliance and improve rehabilitation outcomes for children with physical disabilities.