Aim: The present study assessed the relationship between mitral valve prolapse and panic disorder. Methods: This prospective study included 45 patients with echocardiographic diagnosis of mitral valve prolapse (MVP) and an equal number of age and sexmatched patients with panic disorder. All subjects underwent evaluation by a cardiologist with echocardiography and psychiatric evaluation by a psychiatrist. Results: Nine (20%) of the MVP patients had PD. Among the PD patients, 5 (16.67%) had asymptomatic MVP. These were significantly higher than in the general population. Abnormal body habitus occurred in 45.8% of patients. The association between thin body habitus and MVP was supported. Prolapse of AML only was associated with less severe symptoms. Conclusion: The high prevalence of panic disorder in MVP patients and of MVP in panic disorder patients is consistent with earlier studies. Panic disorder associated with MVP is no different from uncomplicated panic disorder and responds as well to antidepressants.