AbstractBackground: Hypoalbuminemia is prevalent in patients undergoing major abdominal surgeries and is associated with adverse postoperative outcomes, including prolonged hospital stays, higher infection rates, and increased mortality. The clinical impact of albumin supplementation in these patients remains under scrutiny. Objective: This study evaluates whether al bumin supplementation Background: Hypoalbuminemia is prevalent in patients undergoing major abdominal surgeries and is associated with adverse postoperative outcomes, including prolonged hospital stays, higher infection rates, and increased mortality. The clinical impact of albumin supplementation in these patients remains under scrutiny. Objective: This study evaluates whether albumin supplementation in hypoalbuminemicpatients(≤3.0g/dL)improvespostoperativeoutcomes. Methods: This retrospective study included patients who underwent major abdominal surgery between January 2021 and December 2024 at a tertiary care hospital. Patients with hypoalbuminemia were divided into two cohorts of 250 each: those who received postoperative albumin supplementation and those who did not. Outcomes measured included length of hospital stay (LOS), infection rates, ICU admission rates, and 30-day mortality. Results: Background: Hypoalbuminemia is prevalent in patients undergoing major abdominal surgeries and is associated with adverse postoperative outcomes, including prolonged hospital stays, higher infection rates, and increased mortality. The clinical impact of albumin supplementation in these patients remains under scrutiny. Objective: This study evaluates whether albumin supplementation in hypoalbuminemicpatients(≤3.0g/dL)improvespostoperativeoutcomes. Methods: This retrospective study included patients who underwent major abdominal surgery between January 2021 and December 2024 at a tertiary care hospital. Patients with hypoalbuminemia were divided into two cohorts of 250 each: those who received postoperative albumin supplementation and those who did not. Outcomes measured included length of hospital stay (LOS), infection rates, ICU admission rates, and 30-day mortality. Results: ThealbuminsupplementationgrouphadasignicantlyshorterLOS(8.1 vs. 11.4 days, p < 0.001) and lower infection rates (10% vs. 17%, p = 0.02). There wasno statisticallysignicantdifferenceinICUadmissionsor30-daymortality between the two groups (p = 0.58 and p = 0.19, respectively). Multivariate regression identiedalbuminsupplementationasanindependentpredictorofreducedLOS and infection rates. Conclusion: Albumin supplementation in hypoalbuminemic patients post-major abdominal surgery improves recovery metrics by reducing LOS and infection rates healbuminsupplementationgrouphadasignicantlyshorterLOS(8.1 vs. 11.4 days, p < 0.001) and lower infection rates (10% vs. 17%, p = 0.02). There wasno tatisticallysignicantdifferenceinICUadmissionsor30-daymortality between the two groups (p = 0.58 and p = 0.19, respectively). Multivariate regression identiedalbuminsupplementationasanindependentpredictorofreducedLOS and infection rates. Conclusion: Albumin supplementation in hypoalbuminemic patients post-major abdominal surgery improves recovery metrics by reducing LOS and infection Methods: This retrospective study included patients who underwent major abdominal surgery between January 2021 and December 2024 at a tertiary care hospital. Patients with hypoalbuminemia were divided into two cohorts of 250 each: those who received postoperative albumin supplementation and those who did not. Outcomes measure d included length of hospital stay (LOS), infection rates, ICU admission rates, and 30-day mortality. Results: ealbuminsupplementationgrouphadasignicantlyshorterLOS(8.1 vs. 11.4 days, p < 0.001) and lower infection rates (10% vs. 17%, p = 0.02). There wasno statisticallysignicantdifferenceinICUadmissionsor30-daymortality between the two groups (p = 0.58 and p = 0.19, respectively). Multivariate regression identiedalbuminsupplementationasanindependentpredictorofreducedLOS and infection rates.