AbstractHeparin possesses anti-inflammatory, antihistaminic, anti-allergic, serotoninblocking, and proteolytic enzyme-inhibiting properties. Topical forms of heparin have been used in burn care to prevent burn wound extension, minimize skin tissue loss, promote faster healing with fewer contractures, relieve pain, reduce tissue edema and exudation, prevent infection, and support revascularization, granulation, and epithelialization of deeply burned tissue. Similarly, topical lignocaine in gel form has been applied to raw burn areas and post-skin graft sites, showing significant effectiveness in pain relief. In addition to analgesia, lignocaine has also been shown to reduce edema and post-burn ischemia. In this case report, we discuss the combined use of topical heparin and local anesthetic as part of burn wound management.