Home > Journals > Indian Journal of Forensic Medicine and Pathology

Indian Journal of Forensic Medicine and Pathology

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

A Comparative Study of ART Regimens and the Haematological Effect of ART in Treatment of PLHIV

Swati Singh, Junior Resident, Department of Pathology, R.C.S.M. Govt Medical College and CPR Hospital, Kolhapur, Maharashtra 416002, India. , Singh Swatia , Namey R.D.b

Author Information
Licence:


Indian Journal of Forensic Medicine and Pathology 11(1):p 33-38, . | DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.11118.6
How Cite This Article:
Received : N/A         Accepted : N/A          Published : N/A
Abstract

Background: Haematological manifestations are the second commonest cause of morbidity and one of the common causes of mortality in HIV patients. In the course of ART administration, clinically significant haematologic abnormalities are common in persons with HIV infection. Objectives: To study the comparison of haematological parameters in subjects with different CD4 counts, to compare haematological findings of pre-ART group with ART group and two ART regimens namely ZLN and TLE. Study Design: Prospective observational study. Material and Methods: After obtaining informed consent, 225 PLHIV were clinically evaluated and subjected to CBC, PBS, ALC, ESR and CD4 count. Statistical Analysis: Data was expressed as percentage and mean ± standard deviation. Statistical tests used were chi-square test, Fisher’s exact test and Mann-Whitney U test and Kolmogorov-smirnov analysis. Results: TLC (p=0.02), MCV (p=0.04) and ALC (p<0.0003) were significantly raised while Hb, MCH, MCHC, PCV, ESR, CD4 count showed Non significant raised values in ART group in comparison to pre-ART group. MCH (p=0.01) and ALC (p<0.001) were significantly raised and Hb, MCHC, PCV, ESR, ALC showed Non significant raised values in PLHIV on TLE regimen when compared to ZLN regimen while TLC (p=0.04) was significantly raised in ZLN regimen. Conclusion: Most significant parameter was ALC in comparison between treated and untreated PLHIV groups and two ART regimens. TLE regimen fared better than ZLN regimen in treatment of PLHIV.

Keywords: Haematological; PLHIV; TLE; ZLN. 

References

No records found.

Funding

Author Information

Authors and Affiliatione

  • Swati Singh, Junior Resident, Department of Pathology, R.C.S.M. Govt Medical College and CPR Hospital, Kolhapur, Maharashtra 416002, India.
    ,
  • Singh Swatia
    ,
  • Namey R.D.b
    ,
Conflicts of Interest
Supplementary Information

Below is the link to the supplementary material.

Rights and Permissions


About this article

Cite this article

Licence:


Download citation

Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.11118.6
Keywords

Article Level Metrics

Last Updated

Sunday 08 June 2025, 02:27:56 (IST)

60

Accesses

00
0
00

Citations


22
11
23

View full article metrics including social shares, article views and publishing history


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article


Reprint Order Form
Buy Single Article
Institutional Subscriptions

Share