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Cardiovascular Disease and its Diagnosis with Cardiac Markers

Sachin C Narwadiya. , Gulshan Jagdish Karhade , Jopasana S Adkane , Sachin C Narwadiya

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Journal of Biochemistry and Biophysics 5(1):p 9-13, . | DOI:
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Gulshan Jagdish Karhade, Jopasana S. Adkane, Sachin C Narwadiya. Cardiovascular Disease and its Diagnosis with Cardiac
Markers. RFP Journal of Biochemistry and Biophysics. 2020;5(1):9–13.
 

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Abstract

Cardiovascular diseases (CVDs) are becoming major cause of deaths in India. Ischemic heart disease and stroke are the are major responsible among the deaths of CVDs. As per the Global Burden of Disease study the CVD death rate of 272 per 100000 populations in India is higher as compared to the global average of 235 per 100000 populations. The markers of various diseases always attract researchers for development of technologies. These technologies are then helpful for the early diagnosis of diseases. The markers of CVDs enable the doctor to diagnose the onset of disease and start its management. Diagnostics measures of Lactate dehydrogenase (LDH), creatine kinase (CK) or aspartate aminotransferase (ASAT) enzymatic activities are good indicator of acute myocardial infarction (AMI). Enzymatic assessment and myoglobin findings slowly replacing with assessment of cardiac
troponins (I and T) and its high sensitivity versions are leading to help in acute myocardial infarction Diagnostics. Many tests were performed to assess the severity of the heart failure in case of recent onset of heart attack but more emphasis is on the development of markers which can be used in cardiovascular disease prevention and reduced
risk of cardiovascular disease.3 The cardiac troponins is mostly used as cardiac markers for the diagnostics for Acute coronary syndrome and
MI patient with elevated troponin levels but negative creatine kinase - MB (CK - MB) use in diagnosed in unstable
angina or minor myocardial injury.2


Keywords: Cardiovascular disease; Lactate dehydrogenase (LDH); Creatine kinase (CK); Cardiac troponins (I andT)
 

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  • Sachin C Narwadiya.
    ,
  • Gulshan Jagdish Karhade
    ,
  • Jopasana S Adkane
    ,
  • Sachin C Narwadiya
    ,
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Gulshan Jagdish Karhade, Jopasana S. Adkane, Sachin C Narwadiya. Cardiovascular Disease and its Diagnosis with Cardiac
Markers. RFP Journal of Biochemistry and Biophysics. 2020;5(1):9–13.
 

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