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Clinical Identification & Anti-fungal Susceptibility of Candida Species by Vitek-2 System

Sheetal Sharma , Sheetal Sharma1 , Vipin Kathuria2 , Kuldeep Yadav3 , S.K Datta4

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Journal of Microbiology and Related Research 10(1):p 15-20, . | DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.10124.2
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Sheetal Sharma, Vipin Kathuria, Kuldeep Yadav et al. Clinical Identification & Anti-fungal Susceptibility of Candida Species by
Vitek-2 System. J Microbiol Relat Res. 2024;10(1):15–20.
 

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Abstract

Introduction: Among fungal infections, invasive candidiasis is often associated  with increased number of morbidity and death rate. Candida species causing so many  infections range from non fatal mucocutaneous infections to fatal blood stream infections,
so the aim of this study is isolate and speciate the Candida species and their anti-fungal  susceptibility to avoid unnecessarily consumption of anti-fungal drugs.  Material & Methods: A Prospective study which was carried out in the Department of
Microbiology, Pacific Institute of Medical Sciences Udaipur. Specimen collected from the various sites were collected and cultured on SDA agar and incubated. Identification of  Candida species was done through Hi-Crome Candida Differential Agar and anti-fungal  susceptibility was evaluated by VITEK-2 automated system and results were calculated  through statistical analysis.
Results: Out of 64 Candida isolates, 34.38% were Candida albicans, followed by Candida  tropicalis (31.25%) Candida krusei (20.31%), Candida kefyr (12.50%) and Candida glabrata  (1.56%). The most common Candida species isolated from urine were Candida albicans (34.24%) followed by Candida tropicalis (31.25%). Voriconazole (92.19%) and Amphotericin  B (89.06%) were found the most sensitive drugs against the Candida isolates followed  by Flucytosine (79.69%), Caspofungin (76.56%), Micafungin (70.31%) and Fluconazole  (62.50%). All the Candida kefyr isolates were susceptible to Voriconazole, AmphotericinB and Flucytosine and resistant to Fluconazole. all Candida glabrata isolates were susceptible to all the 4 drugs except
Micafungin and Caspofungin.  Conclusion: The present study shows the distribution of Candida species in
various clinical specimens and also  revealed that Non-albicans Candida species are emerging as the predominant species.
The increased resistance of Candida isolates  towards common anti-fungal drugs which is a concern around all over the world
 

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Authors and Affiliatione

  • Sheetal Sharma
    ,
  • Sheetal Sharma1
    ,
  • Vipin Kathuria2
    ,
  • Kuldeep Yadav3
    ,
  • S.K Datta4
    ,
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Sheetal Sharma, Vipin Kathuria, Kuldeep Yadav et al. Clinical Identification & Anti-fungal Susceptibility of Candida Species by
Vitek-2 System. J Microbiol Relat Res. 2024;10(1):15–20.
 

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DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.10124.2
Keywords Composting; Plastic Bag; Plant Growth study; Physio-Chemical Properties; Nutrient Loss

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