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Concentration of Neurotransmitter Metabolite 5-hydroxyindoleacetic Acid (5-HIAA) in Cerebrospinal Fluid of Individuals with Suicidal Tendencies: A Meta-Analysis

Sharma R , Ravi Prakash M1 , Sharma R2 , Bhute AR3 , Bastia BK4

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Indian Journal of Forensic Medicine and Pathology 12(3 ):p 173-178, . | DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.12319.2
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Abstract

Review of 28 research articles on the cerebrospinal fluid levels of neurotransmitter metabolites involving 1942 psychiatric patients found a strong evidence of involvement of serotonin system in suicidal behavior. All the individuals who attempted suicide, especially those using violent methods, had lower levels of CSF 5-hydroxyindoleacetic acid (5-HIAA) as compared to those in the controls. The Meta-analysis attempts to draw more reliable conclusion than did each individual study alone.

Keywords: Cerebrospinal fluid; Neurotransmitter metabolites; 5-HIAA.

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  • Sharma R
    ,
  • Ravi Prakash M1
    ,
  • Sharma R2
    ,
  • Bhute AR3
    ,
  • Bastia BK4
    ,
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DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.12319.2
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