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Case Report

Counselling Considerations for Chromosomal Mosaicism after Embryo Biopsy PGT-A: A Case Report

G. Shiva Krishna, Senior Embryologist, Department of Reproductive Medicine, Laxmi Narasimha Hospital, Kishanpura, Hanamkonda 506001, Telangana, India. , G. Shiva Krishna 1 , Amit Jhajariya 2

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Indian Journal of Biology 10(2):p 77-82, . | DOI: http://dx.doi.org/10.21088/ijb.2394.1391.10223.3
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G. Shiva Krishna, Amit Jhajariya/Counselling Considerations for Chromosomal Mosaicism after Embryo Biopsy PGT-A: A Case Report/Indian J Biol 2023; 10(2):77–82.
 

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Abstract

Pre-implantation genetic testing for aneuploidy PGT-A is a genetic test performed on Day 5 or Day 6 embryos obtained through Invitro fertilization (IVF). Embryo Biopsy is a procedure where the part of Trophoectoderm of the embryo is taken and sent for PGT-A analysis. PGT-A is indicated in couple who has been through previous miscarriage, maternal age >35 years and previous child anomalies. Mosaicism is a condition in which the presence of two or more abnormal cell lines or a normal and an abnormal cell line has observed. Embryonic mosaicism might play a significant role in pregnancy loss after IVF, cytogenetic and array based analysis of miscarriages following spontaneously conceived pregnancies commonly reveal chromosomal mosaicism. The degree of Embryonic Mosaicism negatively affects the implantation rate.
 

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  • G. Shiva Krishna, Senior Embryologist, Department of Reproductive Medicine, Laxmi Narasimha Hospital, Kishanpura, Hanamkonda 506001, Telangana, India.
    ,
  • G. Shiva Krishna 1
    ,
  • Amit Jhajariya 2
    ,
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Cite this article

G. Shiva Krishna, Amit Jhajariya/Counselling Considerations for Chromosomal Mosaicism after Embryo Biopsy PGT-A: A Case Report/Indian J Biol 2023; 10(2):77–82.
 

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DOI: http://dx.doi.org/10.21088/ijb.2394.1391.10223.3
Keywords PGT-A; Genetic Counselling; Embryo Biopsy; Aneuploidy.

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