" "
Home > Journals > Journal of Pharmaceutical and Medicinal Chemistry

Journal of Pharmaceutical and Medicinal Chemistry

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Hepatoprotective Activity of Ethonolic Extract of Allophylus Serratus Root

Ishwar Chandra Giri* , Ishwar Chandra Giri* , Lal Shikhar Singh** , Sandeep Kumar Singh*** , Prakash Deep**** , Vijayendra Kr Pandey*****

Author Information
Licence:


Journal of Pharmaceutical and Medicinal Chemistry 2(1):p 27-34, . | DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2116.3
How Cite This Article:
Received : N/A         Accepted : N/A          Published : N/A
Abstract

 In the present study we selected a plant namely allophylus serratus belonging to the family (sapindaceae) commonly known as Triputa (in Sanskrit). It is a large shrub or small tree grows up to 10 meters in height. It contains beta-sitosterol, phenacetamide, two flavonoid glycosides like luteolin-7-o-[beta]-D-glucopyranoside and apigenin- 4’-o[beta]-D-glucoside, quercetin, pinitol, rutin etc. It is useful in bone fractures, dislocations, Inflammations, ulcers, wounds, dyspepsia, anorexia and diarrhoea. The fruits are sweet cooling and nourishing tonic. Roots of widely grown plant Allophylus serratus reported to possess a very high amount of polyphenols and gallic acid which are well known potent antioxidants. Evaluation of the hepatoprotective activity was done by estimating the biochemical marker like SGPT, SGOT, ALP, LDH, total bilirubin, total protein in serum. EEAS significantly reversed the above parameters to near normal levels and the activity of EEAS was comparable to that of standard silymarin. The present studies indicated that the EEAS possess potent hepatoprotective activity comparable to standard LIV 52. The possible hepatoprotective mechanism of roots of llophylus serratus may be via its antioxidant property. 

Keywords: EEAS; Hepatotoxins; CCl 4, Histopathology.

References

No records found.

Funding

Author Information

Authors and Affiliatione

  • Ishwar Chandra Giri*
    ,
  • Ishwar Chandra Giri*
    ,
  • Lal Shikhar Singh**
    ,
  • Sandeep Kumar Singh***
    ,
  • Prakash Deep****
    ,
  • Vijayendra Kr Pandey*****
    ,
Conflicts of Interest
Supplementary Information

Below is the link to the supplementary material.

Rights and Permissions


About this article

Cite this article

Licence:


Download citation

Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2116.3
Keywords

Article Level Metrics

Last Updated

Sunday 08 June 2025, 01:46:56 (IST)

5

Accesses

00
0
00

Citations


22
11
23

View full article metrics including social shares, article views and publishing history


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article


Reprint Order Form
Buy Single Article
Institutional Subscriptions

Share