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Histological Pattern of IgA Nephropathy (IgAN) by Oxford Classification by MEST Scoring

Lakshminarayana G.R , Lakshminarayana G.R.* , Ranjit Narayanan** , Raghunath K.V.* , Indu S.* , Seethalekshmy N.V.*** , Biju M.V.****

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Urology, Nephrology and Andrology International 1(1):p 33-38, . | DOI:
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Abstract

 IgAN is one of the commonest biopsy proven primary glomerular diseases with diverse histological patterns based on the geographic location. This is a study was done by including all consecutive cases of biopsy proven IgAN(native kidney) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to February 2016. We had 62 (Females: 36, Males: 26) cases of biopsy proven IgAN. The mean age of the patients was 37.71 years and male: female ratio was 1.38:1. The IgAN was classified according to the Oxford classification (MEST scoring). Majority of the patients had mesangial hypercellularity (91.94%) and tubular atrophy (69.36%; T1- 43.55%, T2-25.81%). Only few patients had endocapillary proliferation (20.97 %), and segmental sclerosis (39.68 %). Glomerular crescents (involving 5-20% of glomeruli) were found in 4.84 % of patients with IgAN. The commonest combinations of MEST scoring were M1, E0, S0, T1 (25.81%), followed by M, E0, S1, T1 (14.52%) and M0, E0, S0, T0, was seen only in 6.45% of cases. This study confirms the aggressive nature of IgAN in Indian subcontinent, unlike western literature.


Keywords: IgAN; Oxford-MEST Classification.

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  • Lakshminarayana G.R
    ,
  • Lakshminarayana G.R.*
    ,
  • Ranjit Narayanan**
    ,
  • Raghunath K.V.*
    ,
  • Indu S.*
    ,
  • Seethalekshmy N.V.***
    ,
  • Biju M.V.****
    ,
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