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Spectrum of Gastrointestinal Polyps in Children: Does Eosinophilic Infiltration in Juvenile Polyps Have Any Significance?

Ramani Malleboyina , Ramani Malleboyina , Afshan Jabeen , Ramesh Reddy , Sreenivas Reddy , MS , Othuluru H. Radhika , Kayla Geetha

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Indian Journal of Pathology: Research and Practice 2(1):p 19-24, . | DOI:
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Abstract

Context: Gastrointestinal polyps are common in children with juvenile polyps being the most common type, accounting for 90% of cases.[1] The reported incidence of juvenile polyposis syndrome is between 1 in 100,000-1 in 160,000.[2] Present study reviews histopathology, distribution and clinical manifestations of gastrointestinal polyps in children and significance of mucosal eosinophilia in Juvenile polyps. A comprehensive knowledge of these disorders is necessary for correct treatment and follow up. Aims: To study histology and distribution of intestinal polyps and to analyze significance of stromal eosinophilia in the pathogenesis of Juvenile polyps. Settings and Design: Three year retrospective and two year prospective study between May 2007 and April 2012. Methods and Materials: Forty two cases of gastrointestinal polyps in children were studied. Polyp size, number and location were noted. Association between stromal eosinophilia and age/size in case of juvenile polyps was studied. Statistical analysis: Chi square test (PSPP software) Results: There were thirty four solitary juvenile polyps, two multiple juvenile polyposis cases, three inflammatory polyps and three Peutz Jeghers polyps. Most common site was rectum and mean age was 6.7 years. Eosinophilic infiltration showed positive correlation with size and inverse correlation with age in juvenile polyps.Conclusions: Majority of polyps in children are solitary juvenile  polyps. Presence of significant eosinophilic infiltration of polyps may suggest a role of allergy in etiopathogenesis of juvenile polyps. 

Keywords: Eosinophilic infiltration; Gastrointestinal polyps; Pediatric polyps. 

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  • Ramani Malleboyina
    ,
  • Ramani Malleboyina
    ,
  • Afshan Jabeen
    ,
  • Ramesh Reddy
    ,
  • Sreenivas Reddy
    ,
  • MS
    ,
  • Othuluru H. Radhika
    ,
  • Kayla Geetha
    ,
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