Home > Journals > Indian Journal of Forensic Medicine and Pathology

Indian Journal of Forensic Medicine and Pathology

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Ultrastructure of Cerebral Cortex Investigation during Early Postmortem Changes in a Rat Model

Ahmed Medhat Hegazy, 1Lecturer, Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Aswan University, P.O. Box 81528 Aswan, Egypt , Ahmed Medhat Hegazy1 , Soad M Nasr2 , Sekena H Abdel Aziem3

Author Information
Licence:


Indian Journal of Forensic Medicine and Pathology 13(3):p 365-376, . | DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.13320.1
How Cite This Article:

Ahmed Medhat Hegazy, Soad M Nasr, Sekena H Abdel-Aziem. Ultrastructure of Cerebral Cortex Investigation during Early
Postmortem Changes in a Rat Model. Indian J Forensic Med Pathol. 2020;13(3):365–375.
 

Received : N/A         Accepted : N/A          Published : N/A
Abstract


Estimation of the postmortem interval (PMI) is a very essential task for forensic experts,especially in criminal cases. The PMI is the time passed since the death of an individual and refers to the stages of autolysis. The current study was designed to estimate PMI by determination of
the oxidative markers, RNA integrity, GAPDH mRNA level in the brain of adult male albino rats and the autolytic ultrastructure changes of the cerebrum at time of death (0 hour), and then on 1st, 2nd, 4th, and 6th hours postmortem (hpm). Thirty-five male albino Wistar rats were
included in the present study (Seven rats for each time). The results revealed a significant timedependent malondialdehyde elevation with a decrease the antioxidant CAT, SOD, and GSH started from the 1st till the 6th hpm. On the other hand, the brain tissue GAPDH-mRNA gene
expression level showed a significant decrease at the 1st and the 6th hpm. The ultrastructure changes showed significant autolytic changes in the nerve cell, the nerve axon, and the blood vessels starting from the 1st till the 6th hpm. In conclusion, oxidative markers and ultrastructure
examination of the brain tissue especially cerebrum could be helpful for determination the early postmortem interval time.


Keywords: Postmortem; Oxidant/Antioxidant status; Molecular; Ultrastructure; Brain
 

References

No records found.

Funding

Author Information

Authors and Affiliatione

  • Ahmed Medhat Hegazy, 1Lecturer, Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Aswan University, P.O. Box 81528 Aswan, Egypt
    ,
  • Ahmed Medhat Hegazy1
    ,
  • Soad M Nasr2
    ,
  • Sekena H Abdel Aziem3
    ,
Conflicts of Interest
Supplementary Information

Below is the link to the supplementary material.

Rights and Permissions


About this article

Cite this article

Ahmed Medhat Hegazy, Soad M Nasr, Sekena H Abdel-Aziem. Ultrastructure of Cerebral Cortex Investigation during Early
Postmortem Changes in a Rat Model. Indian J Forensic Med Pathol. 2020;13(3):365–375.
 

Licence:


Download citation

Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.13320.1
Keywords

Article Level Metrics

Last Updated

Sunday 08 June 2025, 01:20:01 (IST)

60

Accesses

00
0
00

Citations


22
11
23

View full article metrics including social shares, article views and publishing history


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article


Reprint Order Form
Buy Single Article
Institutional Subscriptions

Share