" "
Home > Journals > Journal of Microbiology and Related Research

Journal of Microbiology and Related Research

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Antinuclear Antibody (ANA) Pattern Distribution & Clinical Relationship in a Tertiary Care Centre

Thomas S Kuruvilla , Thomas S Kuruvilla1 , Pampi Majumder2

Author Information
Licence:


Journal of Microbiology and Related Research 5(2):p 99-103, . | DOI: DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.5219.7
How Cite This Article:

Thomas S Kuruvilla, Pampi Majumder. Antinuclear Antibody (ANA) Pattern Distribution & Clinical Relationship in a Tertiary Care Centre. J Microbiol Relat Res. 2019;5(2):99-103.

Received : N/A         Accepted : N/A          Published : N/A
Abstract

Introduction: Antinuclear antibodies (ANA’s), are one of the most important tests in immunology, although very informative it faces major challenges. Confronting a positive ANA in a patient without clinical disease but consistent symptoms, is a game changer for the treating physician. This study aims to determine the rate & pattern of ANA positivity and understand its distribution pattern and clinical diagnosis in cases evaluated at a tertiary care centre. Materials and Methods: This observational analytical study was carried out for a period of one year. A single serum sample was collected from patients ranging from age groups 10 to 65 yrs suspected to have an autoimmune disease. Samples were tested by indirect immunofluoresence (IIF) and patterns were recorded and analysed. Results: Among the 150 tests done, 15 (10%) cases were ANA global test positive, with a mean age was 40 and greater positivity among females patients 16 (17.3%) (p-value <0.001). The most common pattern encountered was the nucleoplasm fine granular variety 10 (40%) followed by nucleoplasm coarse granular 5 (20%).Various other patterns were also observed with a predominance of cell nuclei homogenous pattern 4 (16%). ANA positivity was observed in 95% of Systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD) and in 25-70% of the cases with Sjögren syndrome, Systemic sclerosis (SS) and Rheumatoid arthritis (RA). Some ANA’s showed weak fluorescence detectable before the actual onset of clinical symptoms being apparent and was particularly seen in suspected cases of SLE. Conclusion: The rate and distribution of pattern types correlated well with the autoimmune condition and even borderline or weak intensity fluorescent patterns should be reported and the patients having them should be followed-up regularly.

Keywords: Antinuclear antibodies; Indirect immunofluoresence; Systemic lupus erythematosis.

References

No records found.

Funding

Author Information

Authors and Affiliatione

  • Thomas S Kuruvilla
    ,
  • Thomas S Kuruvilla1
    ,
  • Pampi Majumder2
    ,
Conflicts of Interest
Supplementary Information

Below is the link to the supplementary material.

Rights and Permissions


About this article

Cite this article

Thomas S Kuruvilla, Pampi Majumder. Antinuclear Antibody (ANA) Pattern Distribution & Clinical Relationship in a Tertiary Care Centre. J Microbiol Relat Res. 2019;5(2):99-103.

Licence:


Download citation

Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.5219.7
Keywords

Article Level Metrics

Last Updated

Sunday 08 June 2025, 07:18:31 (IST)

6

Accesses

00
0
00

Citations


22
11
23

View full article metrics including social shares, article views and publishing history


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article


Reprint Order Form
Buy Single Article
Institutional Subscriptions

Share