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Effect of formalin fixation on DNA: A Time-Based Approach

Neeharika Srivastava , Jyoti Gullaiya1 , Naresh Kumar , 2 Neeharika Srivastava3

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Indian Journal of Forensic Medicine and Pathology 14(4):p 825-830, . | DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.14421.7
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How to cite this article Jyoti Gullaiya, Naresh Kumar, Neeharika Srivastava/Effect of formalin fixation on DNA: A Time-Based Approach/Indian Journal of Forensic Medicine and Pathology/2021;14(4):825-830

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Abstract

A B S T RA C T
Introduction:Tissue preservation is important. From it forensic scientist may extract sufficient DNA for profiling. The most commonly used preservative found in the literature is formalin. However, it causes severe side-effects on its users as well as the environment; we need to find its replacement. Method:This study examined whether formalin could preserve soft tissues (fresh) stored at 4°C for 100 days and how DNA can be extracted from it. Qualification and Quantification of the presevred samples were done. Result:The results revealed that tissues preserved in formalin failed to generate sufficient quantity of DNA for profiling whereas tissues preserved in normal saline did so. Conclusion: The study concluded that there is a need to find an alternative to formalin which can preserve the tissue samples well and enable DNA profiling.

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  • Neeharika Srivastava
    ,
  • Jyoti Gullaiya1
    ,
  • Naresh Kumar
    ,
  • 2 Neeharika Srivastava3
    ,
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How to cite this article Jyoti Gullaiya, Naresh Kumar, Neeharika Srivastava/Effect of formalin fixation on DNA: A Time-Based Approach/Indian Journal of Forensic Medicine and Pathology/2021;14(4):825-830

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DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.14421.7
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