Home > Journals > Indian Journal of Forensic Medicine and Pathology

Indian Journal of Forensic Medicine and Pathology

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Study of the Impact of Leucocyte Reduction on the Coagulation Factors in Fresh Frozen Plasma

Femela Muniraj , Vijayashree Raghavan1 , Femela Muniraj

Author Information
Licence:


Indian Journal of Forensic Medicine and Pathology 14(4):p 819-824, . | DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.14421.6
How Cite This Article:

How to cite this article Vijayashree Raghavan, Femela Muniraj/Study of the Impact of Leucocyte Reduction on the Coagulation Factors in Fresh Frozen Plasma /Indian Journal of Forensic Medicine and Pathology/2021;14(4):819-824

Received : N/A         Accepted : N/A          Published : N/A
Abstract

A B S T RA C T
Introduction:Plasma transfusion is required to arrest or prevent bleeding, for various congenital and acquired cases of coagulopathies such as inherited factor deficiencies, disseminated intravascular coagulation, liver disease, post major trauma, etc. Leukocyte reduced blood components are indicated to prevent the febrile nonhemolytic transfusion reactions, Human Leukocyte Antigen (HLA) alloimmunization, transmission of infections such as cytomegalovirus (CMV), and adverse transfusion reactions due to storage lesion. In the present study, the effect of plasma filtration on eight coagulation factors viz. fibrinogen, factors II, V, VII, VIII, IX, X and XI has been studied.Materials and Methods:The plasma separated from the whole blood donation from each of 25 donors was separated into two aliquots. Group-1 included unfiltered fresh frozen plasma; group-2 included fresh frozen plasma which was subjected to pre-storage leukocytereductionbyfiltration.ThelevelsofthecoagulationfactorsFibrinogen,II,V, VII, VIII, IX, X, XI were estimated in each sample in both the groups.Results:There was no statistically significant difference in the levels of any of the coagulation factors included in this study, between the unfiltered and the leukocyte reduced plasma. Group O positive individuals were found to have higher levels of all the coagulation factors. Conclusion:Filtration of plasma has no effect on the coagulation factors. This is the first study where the effect of plasma filtration on eight coagulation factors has been studied. Blood group O positive individuals were found to have higher levels of all the eight coagulation factors.

References

No records found.

Funding

Author Information

Authors and Affiliatione

  • Femela Muniraj
    ,
  • Vijayashree Raghavan1
    ,
  • Femela Muniraj
    ,
Conflicts of Interest
Supplementary Information

Below is the link to the supplementary material.

Rights and Permissions


About this article

Cite this article

How to cite this article Vijayashree Raghavan, Femela Muniraj/Study of the Impact of Leucocyte Reduction on the Coagulation Factors in Fresh Frozen Plasma /Indian Journal of Forensic Medicine and Pathology/2021;14(4):819-824

Licence:


Download citation

Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.14421.6
Keywords

Article Level Metrics

Last Updated

Sunday 08 June 2025, 01:47:46 (IST)

60

Accesses

00
0
00

Citations


22
11
23

View full article metrics including social shares, article views and publishing history


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article


Reprint Order Form
Buy Single Article
Institutional Subscriptions

Share