The significance of soya beans in animal feed and human nutrition has prompted extensive research into their protease inhibitors, particularly due to their impact on digestion and growth inhibition. Despite initial assumptions linking trypsin inhibitors to poor nutritive value, understanding their precise role has proven complex. This article presents a comprehensive review of plant based protein digestibility, focusing on factors influencing bioavailability and the effects of protease inhibitors such as Bowman-Birk and Kunitz-type inhibitors. Drawing from recent literature, it explores the mechanisms underlying growth inhibition and pancreatic hypertrophy, shedding light on the dynamic interplay between protease inhibitors and digestive physiology. Additionally, it discusses the broader implications for human health and the potential of protease inhibitors in shaping plant centric dietary patterns. Through a synthesis of experimental findings, this review provides valuable insights into the intricate relationship between protease inhibitors and plant protein digestibility, offering guidance for future research and dietary practices.

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