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Histochemical Characters of Prostatic Intraepithelial Neoplasia

Shinde Babaji B., Professor, Department of Pathology, DVVPF’s, Medical College, Vilad Ghat, Ahmednagar, Maharashtra 414111, India. , Babaji B. Shinde1 , Narendra H. Wankhede2 , Deshmukh Sanjay3 , Sadhana Khaparde4

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Indian Journal of Forensic Medicine and Pathology 10(3):p 192-195, . | DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.10317.3
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Abstract

Benign Prostatic hyperplasia (BPH) and carcinoma prostate are increasingly frequent with advancing age. Prostatic intraepithelial neoplasia (PIN) is the most established precursor of prostatic carcinoma. HGPIN and prostate cancer share genetic and molecular markers as well, with PIN representing an intermediate stage between benign epithelium and invasive malignant carcinoma. The clinical significance of HGPIN is that it identifies patients at risk for malignancy. Purpose of this study was to find out the incidence of prostatic intraepithelial neoplasia (PIN) and to study the histochemical characters of PIN and prostatic adenocarcinoma. Method: The present study included prostatic tissue specimen of 150 cases received in the pathology Department during period of April 2013 to December 2014. Histopathological evaluation of all cases were done in the department. Results: PIN accounted for 8.6% (13 cases) with a peak incidence in age group of 70-79 years. LGPIN accounted for 8% (12 cases) and HGPIN accounted for 0.6% (1 case).

Keywords: Benign Prostatic Hyperplasia; Prostatic Intraepithelial Neoplasia (PIN). 

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  • Shinde Babaji B., Professor, Department of Pathology, DVVPF’s, Medical College, Vilad Ghat, Ahmednagar, Maharashtra 414111, India.
    ,
  • Babaji B. Shinde1
    ,
  • Narendra H. Wankhede2
    ,
  • Deshmukh Sanjay3
    ,
  • Sadhana Khaparde4
    ,
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DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.10317.3
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