Journal of Aeronautic Dentistry

Group program missions to the moon and Mars will include as many as 24 hours of EVA per crew member per week, which will involve the performance of exploration, science, construction, and maintenance tasks. The effectiveness and success of these missions is dependent on designing EVA systems and protocols that maximize human performance and efficiency while minimizing health and safety risks for crew members.It is very importantl to understand the effects of EVA system design variables such as suit pressure, weight/ mass, joint ranges of motion, and biomedical monitoring on the ability of astronauts to perform safe, efficient, and effective EVAs. This report describe the problems faced by MDRS health officer during two weeks MDRS mission  

Background: Microgravity is associated with an increased of peroxidative. The effect is more pronounced after long duration space flight and can even last for several weeks after landing. Objective: To determine the influence of a simulated microgravity on antioxidant status of the body, 10 healthy volunteers were studied in condition before, during, and just after the simulated microgravity of -6 head -down -tilt (HDT) bed rest for 120 days. We measured the salivary and serum 8-hydroxydeoxyguanosine before, during and recovery of HDT. Results and conclusions: The 8-hydroxydeoxyguanosine showed significant increase in simulating microgravity. The data provides evidence that oxidative stress is among critical nutritional concerns for long duration space travellers.

Key words: Microgravity, 8-hydroxydeoxyguanosine, head -down -tilt 

For many years, the prevailing concept in space human factors research has been that microgravity has an impact on human physiology and astronauts are faced with several health risks during both short and long duration spaceflights. The review of our study found that reversible effect of microgravity is oedema of face, change in taste, abnormal expression of face, teeth pain and xerostomia. The non reversible effects of microgravity such as periodontal disease, dental caries but in different pattern than normal, stone formation in salivary duct, pre cancer or cancer, fracture of maxillary and mandibular bone and xerostomia are more prevalent in astronauts as compared to normal persons. Further study will be required on large scale on long term effects of microgavity on oral cavity to prevent the adverse effects.

Key words: Mars mission, human factors, Microgravity, Aeronautic Dentistry

The effect of microgravity is more pronounced after long-duration space flights and can even last for several weeks after landing. The extensive research is going on the preventation of peroxidative damage due to microgravity. It has been evident that curcumin (diferuloylmethane), a yellow pigment in curry powder exhibits antioxidant, anti-inflammatory, and proapoptotic activities. To determine the preventive effects of curcumin on peroxidative damage due to two bed rest conditions, 20 healthy male volunteers were equally divided into two groups ( 10 with curcumin and 10 without curcumin ). They were studied in condition before, during, and just on bed rest conditions at -6° head-down-tilt (HDT) bed rest for 10 days. We measured the salivary and serum oxidative markers such as Malonaldehyde, 8-hydroxydeoxyguanosine, vitamin C and E just before HDT , during HDT experiment, and in course time of recovery with curcumin and without curcumin groups. The values of serum and salivary Vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to the condition before and during the recovery stage. However, levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin ( Table- 1, P<0.05) . MDA and 8-OHdG levels showed significant increase in simulating microgravity condition as compared to the condition before and in the recovery stage. Hence, curcumin prevent peroxidative damage in simulated conditions. Further study is required on antioxidation actions of curcumin in space microgravity conditions.

Key Words: Curcumin, Serum, Saliva, oxidative stress, two bed rest position, space microgravity. 

 Not Provided.